IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

Diana C. Yánez; Hemant Sahni; Susan Ross; Anisha Solanki; Ching-In Lau; Eleftheria Papaioannou; Alessandro Barbarulo; Rebecca Powell; Ulrike C. Lange; David J. Adams; Martino Barenco; Masahiro Ono; Fulvio D'Acquisto; Anna Furmanski; Tessa Crompton

doi:10.1002/eji.201847692

IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

Diana C. Yánez
, Hemant Sahni
, Susan Ross
, Anisha Solanki
, Ching-In Lau
, Eleftheria Papaioannou
, Alessandro Barbarulo
, Rebecca Powell
, Ulrike C. Lange
, David J. Adams
, Martino Barenco
, Masahiro Ono
, Fulvio D'Acquisto
, Anna Furmanski
, Tessa Crompton

Institute of Biomedical and Environmental Science & Technology (IBEST)

Universidad San Francisco de Quito
University College London
Wellcome Trust
Cancer Research UK
University of Hamburg
Imperial College London
Roehampton University

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

6 Downloads (Pure)

Abstract

T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.

Original language	English
Pages (from-to)	66-78
Journal	European Journal of Immunology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1002/eji.201847692
Publication status	Published - 26 Oct 2018

Keywords

IFITM proteins
T helper cell

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10.1002/eji.201847692

Y-nez et al-2019-European Journal of ImmunologyFinal published version, 2.18 MBLicence: CC BY

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201847692

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Yánez, D. C., Sahni, H., Ross, S., Solanki, A., Lau, C.-I., Papaioannou, E., Barbarulo, A., Powell, R., Lange, U. C., Adams, D. J., Barenco, M., Ono, M., D'Acquisto, F., Furmanski, A., & Crompton, T. (2018). IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation. European Journal of Immunology, 49(1), 66-78. https://doi.org/10.1002/eji.201847692

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title = "IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation",

abstract = "T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.",

keywords = "IFITM proteins, T helper cell",

author = "Y{\'a}nez, \{Diana C.\} and Hemant Sahni and Susan Ross and Anisha Solanki and Ching-In Lau and Eleftheria Papaioannou and Alessandro Barbarulo and Rebecca Powell and Lange, \{Ulrike C.\} and Adams, \{David J.\} and Martino Barenco and Masahiro Ono and Fulvio D'Acquisto and Anna Furmanski and Tessa Crompton",

year = "2018",

month = oct,

day = "26",

doi = "10.1002/eji.201847692",

language = "English",

volume = "49",

pages = "66--78",

journal = "European Journal of Immunology",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag",

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Yánez, DC, Sahni, H, Ross, S, Solanki, A, Lau, C-I, Papaioannou, E, Barbarulo, A, Powell, R, Lange, UC, Adams, DJ, Barenco, M, Ono, M, D'Acquisto, F, Furmanski, A & Crompton, T 2018, 'IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation', European Journal of Immunology, vol. 49, no. 1, pp. 66-78. https://doi.org/10.1002/eji.201847692

TY - JOUR

T1 - IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

AU - Yánez, Diana C.

AU - Sahni, Hemant

AU - Ross, Susan

AU - Solanki, Anisha

AU - Lau, Ching-In

AU - Papaioannou, Eleftheria

AU - Barbarulo, Alessandro

AU - Powell, Rebecca

AU - Lange, Ulrike C.

AU - Adams, David J.

AU - Barenco, Martino

AU - Ono, Masahiro

AU - D'Acquisto, Fulvio

AU - Furmanski, Anna

AU - Crompton, Tessa

PY - 2018/10/26

Y1 - 2018/10/26

N2 - T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.

AB - T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.

KW - IFITM proteins

KW - T helper cell

U2 - 10.1002/eji.201847692

DO - 10.1002/eji.201847692

M3 - Article

SN - 0014-2980

VL - 49

SP - 66

EP - 78

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 1

ER -

IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

Abstract

Keywords

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