Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

Diana C. Yánez; Ching-In Lau; Mira Manilal Chawda; Susan Ross; Anna Furmanski; Tessa Crompton

doi:10.1016/j.jaci.2019.07.011

Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

Diana C. Yánez
, Ching-In Lau
, Mira Manilal Chawda
, Susan Ross
, Anna Furmanski
, Tessa Crompton

Institute of Biomedical and Environmental Science & Technology (IBEST)

Universidad San Francisco de Quito
University College London

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

7 Downloads (Pure)

Abstract

Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.

Original language	English
Pages (from-to)	1419-1423
Journal	Journal of Allergy and Clinical Immunology
Volume	144
Issue number	5
DOIs	https://doi.org/10.1016/j.jaci.2019.07.011
Publication status	Published - 24 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Immune response
Organisation and Biological Functions
immunology

Access to Document

10.1016/j.jaci.2019.07.011

PIIS0091674919309480Accepted author manuscript, 4.22 MBLicence: CC BY-NC-ND
1-s2.0-S0091674919309480-mainFinal published version, 1.04 MBLicence: CC BY

https://www.jacionline.org/article/S0091-6749%2819%2930948-0/abstract

Handle.net

Persistent link

Cite this

@article{d78769ae4ec542ed8b442b18f1b359c2,

title = "Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells",

abstract = "Original journal article Abstract: Here we show that differentiation of human na{\"i}ve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.",

keywords = "Immune response, Organisation and Biological Functions, immunology",

author = "Y{\'a}nez, \{Diana C.\} and Ching-In Lau and Chawda, \{Mira Manilal\} and Susan Ross and Anna Furmanski and Tessa Crompton",

year = "2019",

month = jul,

day = "24",

doi = "10.1016/j.jaci.2019.07.011",

language = "English",

volume = "144",

pages = "1419--1423",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier B.V.",

number = "5",

}

TY - JOUR

T1 - Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

AU - Yánez, Diana C.

AU - Lau, Ching-In

AU - Chawda, Mira Manilal

AU - Ross, Susan

AU - Furmanski, Anna

AU - Crompton, Tessa

PY - 2019/7/24

Y1 - 2019/7/24

N2 - Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.

AB - Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.

KW - Immune response

KW - Organisation and Biological Functions

KW - immunology

UR - https://www.sciencedirect.com/science/article/pii/S0091674919309480

U2 - 10.1016/j.jaci.2019.07.011

DO - 10.1016/j.jaci.2019.07.011

M3 - Article

SN - 0091-6749

VL - 144

SP - 1419

EP - 1423

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 5

ER -

Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

Abstract

UN SDGs

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

Cite this