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Gut hormone regulation and secretion via FFA1 and FFA4

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

32 Citations (Scopus)

Abstract

The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4.
Original languageEnglish
Title of host publicationFree Fatty Acid Receptors
PublisherSpringer
Volume236
DOIs
Publication statusPublished - 22 Nov 2016

Publication series

NameHandbook of Experimental Pharmacology
Number236

Keywords

  • CCK
  • FFA1
  • FFA4
  • GIP
  • GLP-1
  • Ghrelin
  • Incretin

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