TY - JOUR
T1 - Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain
T2 - A Multicenter Study
AU - Pérez-Sáez, María José
AU - Melilli, Edoardo
AU - Arias, Marta
AU - Franco, Antonio
AU - Martínez, Rocío
AU - Sancho, Asunción
AU - Molina, María
AU - Facundo, Carme
AU - Polanco, Natalia
AU - López, Verónica
AU - Mazuecos, Auxiliadora
AU - Cabello, Sheila
AU - González García, María Elena
AU - Suárez, María Luisa
AU - Auyanet, Ingrid
AU - Espi, Jordi
AU - García Falcón, Teresa
AU - Ruiz, Juan Carlos
AU - Galeano, Cristina
AU - Artamendi, Marta
AU - Rodríguez-Ferrero, María Luisa
AU - Portolés, José María
AU - Santana, María Auxiliadora
AU - Martín-Moreno, Paloma Leticia
AU - Arhda, Nisrine
AU - Calvo, Marta
AU - Mendiluce, Alicia
AU - Macía, Manuel
AU - Pérez-Tamajón, María Lourdes
AU - de Teresa, Javier
AU - Gascó, Blanca
AU - Soriano, Sagrario
AU - Tabernero, Guadalupe
AU - de la Vara, Lourdes
AU - Ramos, Ana María
AU - Martínez, Rafael
AU - Montero de Espinosa, Enrique
AU - Zalve, José Luis
AU - Pascual, Julio
AU - Rodríguez-Mañas, Leocadio
AU - Gutiérrez-Dalmau, Alex
AU - Moreso, Francesc
N1 - Publisher Copyright:
Copyright © 2025 Pérez-Sáez, Melilli, Arias, Franco, Martínez, Sancho, Molina, Facundo, Polanco, López, Mazuecos, Cabello, González García, Suárez, Auyanet, Espi, García Falcón, Ruiz, Galeano, Artamendi, Rodríguez-Ferrero, Portolés, Santana, Martín-Moreno, Arhda, Calvo, Mendiluce, Macía, Pérez-Tamajón, de Teresa, Gascó, Soriano, Tabernero, de la Vara, Ramos, Martínez, Montero de Espinosa, Zalve, Pascual, Rodríguez-Mañas, Gutiérrez-Dalmau and Moreso.
PY - 2025/6/24
Y1 - 2025/6/24
N2 - Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc ≥50 years. Frailty was assessed by the FRAIL scale. Mean age was 64.2 years; 38.4% were female. Median Charlson comorbidity index (CCI) was 6 [4–7] and the total number of medications was 9 [7–12]. We found that 8.2% of patients were frail and 41.5% were pre-frail. Frailty was more frequent among females (60.2% of frail vs. 32.8% of robust; p < 0.001), hemodialysis patients (74.5% of frail vs. 67.1% of robust; p = 0.02), and those with a high burden of disease (54.6% of frail patients with CCI >6 vs. 29.3% of robust; p < 0.001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3.9 [2.5–6.2]); higher CCI (>6 OR 2.9 [1.6–54]); and the number of medications (OR –per medication- 1.13 [1.07–1.2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them.
AB - Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc ≥50 years. Frailty was assessed by the FRAIL scale. Mean age was 64.2 years; 38.4% were female. Median Charlson comorbidity index (CCI) was 6 [4–7] and the total number of medications was 9 [7–12]. We found that 8.2% of patients were frail and 41.5% were pre-frail. Frailty was more frequent among females (60.2% of frail vs. 32.8% of robust; p < 0.001), hemodialysis patients (74.5% of frail vs. 67.1% of robust; p = 0.02), and those with a high burden of disease (54.6% of frail patients with CCI >6 vs. 29.3% of robust; p < 0.001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3.9 [2.5–6.2]); higher CCI (>6 OR 2.9 [1.6–54]); and the number of medications (OR –per medication- 1.13 [1.07–1.2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them.
KW - FRAIL
KW - candidate
KW - frailty
KW - kidney transplant
KW - waiting list
KW - Prevalence
KW - Cross-Sectional Studies
KW - Comorbidity
KW - Humans
KW - Middle Aged
KW - Risk Factors
KW - Male
KW - Kidney Transplantation
KW - Sex Factors
KW - Female
KW - Aged
KW - Spain/epidemiology
KW - Frailty/epidemiology
UR - https://www.scopus.com/pages/publications/105010782252
U2 - 10.3389/ti.2025.14098
DO - 10.3389/ti.2025.14098
M3 - Article
C2 - 40630784
AN - SCOPUS:105010782252
SN - 0934-0874
VL - 38
JO - Transplant International
JF - Transplant International
M1 - 14098
ER -