Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

Jing Hu; Jie Jiao; Ying Wang; Mingyan Gao; Zhengcheng Lu; Fan Yang; Cuihua Hu; Zhengxun Song; Yujuan Chen; Zuobin Wang

doi:10.1016/j.micron.2019.102710

Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

Jing Hu
, Jie Jiao
, Ying Wang
, Mingyan Gao
, Zhengcheng Lu
, Fan Yang
, Cuihua Hu
, Zhengxun Song
, Yujuan Chen
, Zuobin Wang

Institute for Research in Applicable Computing (IRAC)

Changchun University of Science and Technology
University of Bedfordshire

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

4 Downloads (Pure)

Abstract

Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.

Original language	English
Article number	102710
Journal	Micron
Volume	124
DOIs	https://doi.org/10.1016/j.micron.2019.102710 https://doi.org/10.1016/j.micron.2019.102710
Publication status	Published - 2 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anti-tumour effect
ginseng-extracted compounds
hepatocelluar carcinoma

ASJC Scopus subject areas

Structural Biology
Cell Biology

Access to Document

HujingAccepted author manuscript, 1.17 MBLicence: CC BY-NC-ND

https://www.sciencedirect.com/science/article/pii/S0968432819301337%3Fvia%3Dihub

Handle.net

Persistent link

Cite this

@article{2b646353d58a40aba2a51adf75629a23,

title = "Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro",

abstract = "Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.",

keywords = "anti-tumour effect, ginseng-extracted compounds, hepatocelluar carcinoma",

author = "Jing Hu and Jie Jiao and Ying Wang and Mingyan Gao and Zhengcheng Lu and Fan Yang and Cuihua Hu and Zhengxun Song and Yujuan Chen and Zuobin Wang",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.micron.2019.102710",

language = "English",

volume = "124",

journal = "Micron",

issn = "0968-4328",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

AU - Hu, Jing

AU - Jiao, Jie

AU - Wang, Ying

AU - Gao, Mingyan

AU - Lu, Zhengcheng

AU - Yang, Fan

AU - Hu, Cuihua

AU - Song, Zhengxun

AU - Chen, Yujuan

AU - Wang, Zuobin

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.

AB - Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.

KW - anti-tumour effect

KW - ginseng-extracted compounds

KW - hepatocelluar carcinoma

UR - https://www.scopus.com/pages/publications/85068259302

U2 - 10.1016/j.micron.2019.102710

DO - 10.1016/j.micron.2019.102710

M3 - Article

C2 - 31280008

SN - 0968-4328

VL - 124

JO - Micron

JF - Micron

M1 - 102710

ER -

Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Handle.net

Other files and links

Fingerprint

Cite this