Cleavage of Mer Tyrosine Kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

Ah-Lai Law; Célia Parinot; Jonathan Chatagnon; Basile Gravez; José Alain Sahel; Shomi S. Bhattacharya; Emeline F. Nandrot

doi:10.1074/jbc.M114.628297

Cleavage of Mer Tyrosine Kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

Ah-Lai Law
, Célia Parinot
, Jonathan Chatagnon
, Basile Gravez
, José Alain Sahel
, Shomi S. Bhattacharya
, Emeline F. Nandrot

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

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Abstract

Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.

Original language	English
Pages (from-to)	4941-4952
Journal	Journal of Biological Chemistry
Volume	290
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M114.628297
Publication status	Published - 20 Feb 2015

Keywords

phagocytosis

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10.1074/jbc.M114.628297

final published versionFinal published version, 2.38 MBLicence: CC BY

https://www.jbc.org/content/290/8/4941.long

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title = "Cleavage of Mer Tyrosine Kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis",

abstract = "Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.",

keywords = "phagocytosis",

author = "Ah-Lai Law and C{\'e}lia Parinot and Jonathan Chatagnon and Basile Gravez and Sahel, \{Jos{\'e} Alain\} and Bhattacharya, \{Shomi S.\} and Nandrot, \{Emeline F.\}",

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T1 - Cleavage of Mer Tyrosine Kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

AU - Law, Ah-Lai

AU - Parinot, Célia

AU - Chatagnon, Jonathan

AU - Gravez, Basile

AU - Sahel, José Alain

AU - Bhattacharya, Shomi S.

AU - Nandrot, Emeline F.

PY - 2015/2/20

Y1 - 2015/2/20

N2 - Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.

AB - Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.

KW - phagocytosis

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335232/

U2 - 10.1074/jbc.M114.628297

DO - 10.1074/jbc.M114.628297

M3 - Article

SN - 0021-9258

VL - 290

SP - 4941

EP - 4952

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Cleavage of Mer Tyrosine Kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

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