Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells

Zahara Latif Chaudhry; Bushra Ahmed

doi:10.1179/1743132812Y.0000000135

Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells

Zahara Latif Chaudhry
, Bushra Ahmed

Institute of Biomedical and Environmental Science & Technology (IBEST)

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN.

Original language	English
Pages (from-to)	435-440
Journal	Neurological Research
Volume	35
Issue number	4
DOIs	https://doi.org/10.1179/1743132812Y.0000000135
Publication status	Published - 1 Jan 2012

Keywords

caspase

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https://www.tandfonline.com/doi/10.1179/1743132812Y.0000000135

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title = "Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells",

abstract = "The purpose of the study was to establish a suitable model to study Parkinson{\textquoteright}s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN.",

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AU - Ahmed, Bushra

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N2 - The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN.

AB - The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN.

KW - caspase

U2 - 10.1179/1743132812Y.0000000135

DO - 10.1179/1743132812Y.0000000135

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JO - Neurological Research

JF - Neurological Research

IS - 4

ER -

Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells

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