Biomarkers of frailty

Mariam El Assar de la Fuente; Isabel Rodríguez Sánchez; Alejandro Alvarez-Bustos; Leocadio Rodríguez-Mañas

doi:10.1201/9781003398295-3

Biomarkers of frailty

Mariam El Assar de la Fuente
, Isabel Rodríguez Sánchez
, Alejandro Alvarez-Bustos
, Leocadio Rodríguez-Mañas

University of Bedfordshire

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Numerous biomarkers have been proposed to identify the multisystemic age-related syndrome of frailty. Nevertheless, due to its intricate pathophysiology and the lack of a consensus on a comprehensive and universally accepted definition, identifying a single biomarker or set of biomarkers that definitively characterize frailty, its prognosis, and the response to treatment remains challenging. This review examines the principal laboratory biomarkers associated with pathways closely linked to frailty, such as inflammation, oxidative stress, mitochondrial dysfunction, metabolic and endocrine alterations, among others, plus a summary of imaging biomarkers. Given the multifactorial nature of frailty, it is becoming increasingly imperative to evaluate the role of biomarker sets and the combination of laboratory and imaging biomarkers with the clinical criteria for the diagnosis and prognosis of the different frailty-related outcomes, addressing a crucial need in routine clinical practice.

Original language	English
Title of host publication	Frailty Syndrome
Subtitle of host publication	Basic and Clinical Aspects
Editors	María Carmen Gómez-Cabrera, José Viña, Leocadio Rodríguez-Mañas
Publisher	CRC Press
Pages	36-69
Number of pages	34
ISBN (Electronic)	9781040417980
ISBN (Print)	9781032503882
DOIs	https://doi.org/10.1201/9781003398295-3
Publication status	Published - 4 Sept 2025

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology

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title = "Biomarkers of frailty",

abstract = "Numerous biomarkers have been proposed to identify the multisystemic age-related syndrome of frailty. Nevertheless, due to its intricate pathophysiology and the lack of a consensus on a comprehensive and universally accepted definition, identifying a single biomarker or set of biomarkers that definitively characterize frailty, its prognosis, and the response to treatment remains challenging. This review examines the principal laboratory biomarkers associated with pathways closely linked to frailty, such as inflammation, oxidative stress, mitochondrial dysfunction, metabolic and endocrine alterations, among others, plus a summary of imaging biomarkers. Given the multifactorial nature of frailty, it is becoming increasingly imperative to evaluate the role of biomarker sets and the combination of laboratory and imaging biomarkers with the clinical criteria for the diagnosis and prognosis of the different frailty-related outcomes, addressing a crucial need in routine clinical practice.",

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T1 - Biomarkers of frailty

AU - de la Fuente, Mariam El Assar

AU - Sánchez, Isabel Rodríguez

AU - Alvarez-Bustos, Alejandro

AU - Rodríguez-Mañas, Leocadio

PY - 2025/9/4

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N2 - Numerous biomarkers have been proposed to identify the multisystemic age-related syndrome of frailty. Nevertheless, due to its intricate pathophysiology and the lack of a consensus on a comprehensive and universally accepted definition, identifying a single biomarker or set of biomarkers that definitively characterize frailty, its prognosis, and the response to treatment remains challenging. This review examines the principal laboratory biomarkers associated with pathways closely linked to frailty, such as inflammation, oxidative stress, mitochondrial dysfunction, metabolic and endocrine alterations, among others, plus a summary of imaging biomarkers. Given the multifactorial nature of frailty, it is becoming increasingly imperative to evaluate the role of biomarker sets and the combination of laboratory and imaging biomarkers with the clinical criteria for the diagnosis and prognosis of the different frailty-related outcomes, addressing a crucial need in routine clinical practice.

AB - Numerous biomarkers have been proposed to identify the multisystemic age-related syndrome of frailty. Nevertheless, due to its intricate pathophysiology and the lack of a consensus on a comprehensive and universally accepted definition, identifying a single biomarker or set of biomarkers that definitively characterize frailty, its prognosis, and the response to treatment remains challenging. This review examines the principal laboratory biomarkers associated with pathways closely linked to frailty, such as inflammation, oxidative stress, mitochondrial dysfunction, metabolic and endocrine alterations, among others, plus a summary of imaging biomarkers. Given the multifactorial nature of frailty, it is becoming increasingly imperative to evaluate the role of biomarker sets and the combination of laboratory and imaging biomarkers with the clinical criteria for the diagnosis and prognosis of the different frailty-related outcomes, addressing a crucial need in routine clinical practice.

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A2 - Gómez-Cabrera, María Carmen

A2 - Viña, José

A2 - Rodríguez-Mañas, Leocadio

PB - CRC Press

ER -

Biomarkers of frailty

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