Anti-degranulation response of herbal formula in RBL-2H3 cells

Jing Hu; Yujuan Chen; Jiajing Zhu; Mingyan Gao; Jiani Li; Zhengxun Song; Hongmei Xu; Zuobin Wang

doi:10.1016/j.micron.2019.102819

Anti-degranulation response of herbal formula in RBL-2H3 cells

Jing Hu
, Yujuan Chen
, Jiajing Zhu
, Mingyan Gao
, Jiani Li
, Zhengxun Song
, Hongmei Xu
, Zuobin Wang

Changchun University of Science and Technology
University of Warwick

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.

Original language	English
Journal	Micron
Volume	130
Issue number	102819
DOIs	https://doi.org/10.1016/j.micron.2019.102819
Publication status	Published - 28 Dec 2019

Keywords

anti-degranulation response

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10.1016/j.micron.2019.102819

https://www.sciencedirect.com/science/article/pii/S0968432819303774

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title = "Anti-degranulation response of herbal formula in RBL-2H3 cells",

abstract = "Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.",

keywords = "anti-degranulation response",

author = "Jing Hu and Yujuan Chen and Jiajing Zhu and Mingyan Gao and Jiani Li and Zhengxun Song and Hongmei Xu and Zuobin Wang",

year = "2019",

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doi = "10.1016/j.micron.2019.102819",

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TY - JOUR

T1 - Anti-degranulation response of herbal formula in RBL-2H3 cells

AU - Hu, Jing

AU - Chen, Yujuan

AU - Zhu, Jiajing

AU - Gao, Mingyan

AU - Li, Jiani

AU - Song, Zhengxun

AU - Xu, Hongmei

AU - Wang, Zuobin

PY - 2019/12/28

Y1 - 2019/12/28

N2 - Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.

AB - Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.

KW - anti-degranulation response

U2 - 10.1016/j.micron.2019.102819

DO - 10.1016/j.micron.2019.102819

M3 - Article

SN - 0968-4328

VL - 130

JO - Micron

JF - Micron

IS - 102819

ER -

Anti-degranulation response of herbal formula in RBL-2H3 cells

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