Androgens affect myogenesis in vitro and increase local IGF-1 expression.

Nicholas Sculthorpe; Andrew M. Solomon; Andrea C.M.  Sinanan; Pierre- Marc G. Bouloux; Fergal Grace; Mark P. Lewis

doi:10.1249/MSS.0b013e318237c5c0

Androgens affect myogenesis in vitro and increase local IGF-1 expression.

Nicholas Sculthorpe
, Andrew M. Solomon
, Andrea C.M. Sinanan
, Pierre- Marc G. Bouloux
, Fergal Grace
, Mark P. Lewis

University of Bedfordshire

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.

Original language	English
Pages (from-to)	610-615
Journal	Medicine and Science in Sports and Exercise
Volume	44
Issue number	4
DOIs	https://doi.org/10.1249/MSS.0b013e318237c5c0
Publication status	Published - 1 Apr 2012

Keywords

myogenesis

Access to Document

10.1249/MSS.0b013e318237c5c0

https://journals.lww.com/acsm-msse/fulltext/2012/04000/androgens_affect_myogenesis_in_vitro_and_increase.7.aspx

Handle.net

Persistent link

Cite this

@article{2099bb6c40dd4abc8d6afe207ab3959d,

title = "Androgens affect myogenesis in vitro and increase local IGF-1 expression.",

abstract = "The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.",

keywords = "myogenesis",

author = "Nicholas Sculthorpe and Solomon, \{Andrew M.\} and Sinanan, \{Andrea C.M.\} and Bouloux, \{Pierre- Marc G.\} and Fergal Grace and Lewis, \{Mark P.\}",

year = "2012",

month = apr,

day = "1",

doi = "10.1249/MSS.0b013e318237c5c0",

language = "English",

volume = "44",

pages = "610--615",

journal = "Medicine and Science in Sports and Exercise",

issn = "0195-9131",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Androgens affect myogenesis in vitro and increase local IGF-1 expression.

AU - Sculthorpe, Nicholas

AU - Solomon, Andrew M.

AU - Sinanan, Andrea C.M.

AU - Bouloux, Pierre- Marc G.

AU - Grace, Fergal

AU - Lewis, Mark P.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.

AB - The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.

KW - myogenesis

U2 - 10.1249/MSS.0b013e318237c5c0

DO - 10.1249/MSS.0b013e318237c5c0

M3 - Article

SN - 0195-9131

VL - 44

SP - 610

EP - 615

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 4

ER -

Androgens affect myogenesis in vitro and increase local IGF-1 expression.

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this