A disulfiram-loaded fibers scaffold fabricated via electrospinning method

Chenchen Xie; Ran Ding; Xinyue Wang; Jin Yan; Ying Wang; Wenxiao Zhang; Yingmin Qu; Zuobin Wang

doi:10.1109/3M-NANO46308.2019.8947382

A disulfiram-loaded fibers scaffold fabricated via electrospinning method

Chenchen Xie
, Ran Ding
, Xinyue Wang
, Jin Yan
, Ying Wang
, Wenxiao Zhang
, Yingmin Qu
, Zuobin Wang

Changchun University of Science and Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.

Original language	English
Title of host publication	nan
Publisher	Institute of Electrical and Electronics Engineers Inc.
DOIs	https://doi.org/10.1109/3M-NANO46308.2019.8947382
Publication status	Published - 2 Jan 2020
Event	2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Zhenjiang Duration: 4 Aug 2019 → 8 Aug 2019

Conference

Conference	2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
City	Zhenjiang
Period	4/08/19 → 8/08/19
Other	2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) (04/08/2019-08/08/2019, Zhenjiang)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer treatment
disulfiram
electrospinning
nanofibers scaffold

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10.1109/3M-NANO46308.2019.8947382

https://ieeexplore.ieee.org/document/8947382

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@inproceedings{5287d5e862f64481b526879d6fd33718,

title = "A disulfiram-loaded fibers scaffold fabricated via electrospinning method",

abstract = "In this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.",

keywords = "cancer treatment, disulfiram, electrospinning, nanofibers scaffold",

author = "Chenchen Xie and Ran Ding and Xinyue Wang and Jin Yan and Ying Wang and Wenxiao Zhang and Yingmin Qu and Zuobin Wang",

year = "2020",

month = jan,

day = "2",

doi = "10.1109/3M-NANO46308.2019.8947382",

language = "English",

booktitle = "nan",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

address = "United States",

note = "2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) ; Conference date: 04-08-2019 Through 08-08-2019",

}

Xie, C, Ding, R, Wang, X, Yan, J, Wang, Y, Zhang, W, Qu, Y & Wang, Z 2020, A disulfiram-loaded fibers scaffold fabricated via electrospinning method. in nan. Institute of Electrical and Electronics Engineers Inc., 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), Zhenjiang, 4/08/19. https://doi.org/10.1109/3M-NANO46308.2019.8947382

TY - GEN

T1 - A disulfiram-loaded fibers scaffold fabricated via electrospinning method

AU - Xie, Chenchen

AU - Ding, Ran

AU - Wang, Xinyue

AU - Yan, Jin

AU - Wang, Ying

AU - Zhang, Wenxiao

AU - Qu, Yingmin

AU - Wang, Zuobin

PY - 2020/1/2

Y1 - 2020/1/2

N2 - In this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.

AB - In this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.

KW - cancer treatment

KW - disulfiram

KW - electrospinning

KW - nanofibers scaffold

U2 - 10.1109/3M-NANO46308.2019.8947382

DO - 10.1109/3M-NANO46308.2019.8947382

M3 - Conference contribution

BT - nan

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)

Y2 - 4 August 2019 through 8 August 2019

ER -

A disulfiram-loaded fibers scaffold fabricated via electrospinning method

Abstract

Conference

UN SDGs

Keywords

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